Interactions of ofloxacin and erythromycin with the multidrug resistance protein (MRP) in MRP-overexpressing human leukemia cells.

نویسندگان

  • K Terashi
  • M Oka
  • H Soda
  • M Fukuda
  • S Kawabata
  • K Nakatomi
  • K Shiozawa
  • T Nakamura
  • K Tsukamoto
  • Y Noguchi
  • M Suenaga
  • C Tei
  • S Kohno
چکیده

To investigate interactions between the multidrug resistance protein (MRP) and antimicrobial agents, we examined the effects of 12 agents on vincristine sensitivity and efflux of the calcein acetoxy-methyl ester (calcein-AM) of a MRP substrate in MRP-overexpressing cells. Only ofloxacin and erythromycin enhanced sensitivity with increased intracellular vincristine accumulation and inhibited the calcein-AM efflux. Our findings suggest that the two agents are possible MRP substrates and may competitively inhibit MRP function as a drug efflux pump.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 44 6  شماره 

صفحات  -

تاریخ انتشار 2000